Pancreatic Solid Pseudopapillary Neoplasm: Key Pathologic and Genetic Features.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_CB0EB148CEA5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Pancreatic Solid Pseudopapillary Neoplasm: Key Pathologic and Genetic Features.
Journal
Archives of pathology & laboratory medicine
Author(s)
La Rosa S., Bongiovanni M.
ISSN
1543-2165 (Electronic)
ISSN-L
0003-9985
Publication state
Published
Issued date
01/07/2020
Peer-reviewed
Oui
Volume
144
Number
7
Pages
829-837
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Solid pseudopapillary neoplasm of the pancreas is a low-grade malignant tumor generally associated with a good prognosis. Solid pseudopapillary neoplasms show peculiar morphologic features, but sometimes the differential diagnosis with other pancreatic neoplasms (ie, pancreatic neuroendocrine tumors) can be a challenging task, especially in cytologic or biopsy specimens. In these cases immunohistochemistry is a useful tool, but the diagnostic utility of several proposed immunohistochemical markers is questionable. In recent years, despite several attempts to characterize the pathogenetic, molecular, and prognostic features of solid pseudopapillary neoplasms, they still remain unclear.
To give the reader a comprehensive update on this entity.
The PubMed database (US National Library of Medicine) was searched using the following string: pseudopapillary tumor [AND/OR] neoplasm [AND/OR] pancreas. All articles written in English were included. In addition, because a heterogeneous terminology has been used in the past to define solid pseudopapillary neoplasms, the reference lists of each paper selected in the PubMed database were also reviewed.
This review gives a comprehensive update on the pathologic, clinical, and molecular features of solid pseudopapillary neoplasms, particularly addressing issues and challenges related to diagnosis. In addition, we have tried to correlate the molecular alterations with the morphologic and clinical features.
Keywords
Biomarkers, Tumor/analysis, Biomarkers, Tumor/genetics, Biopsy, Diagnosis, Differential, Genetic Predisposition to Disease, Humans, Immunohistochemistry, Molecular Diagnostic Techniques, Pancreatic Neoplasms/chemistry, Pancreatic Neoplasms/epidemiology, Pancreatic Neoplasms/genetics, Pancreatic Neoplasms/pathology, Phenotype, Predictive Value of Tests, Prognosis
Pubmed
Web of science
Open Access
Yes
Create date
23/01/2020 16:29
Last modification date
02/06/2021 6:36
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