Arachidonic acid augments potassium currents in rat neocortical neurones
Details
Serval ID
serval:BIB_CAFDF15CF040
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Arachidonic acid augments potassium currents in rat neocortical neurones
Journal
Neuroreport
ISSN
0959-4965 (Print)
Publication state
Published
Issued date
04/1993
Volume
4
Number
4
Pages
359-62
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Research Support, Non-U.S. Gov't --- Old month value: Apr
Abstract
We analysed the effects induced by arachidonic acid on voltage-dependent outward currents generated by rat neocortical neurones in culture in the presence of Na+ and Ca2+ channel blockers. These currents, recorded with whole-cell voltage-clamping techniques, were presumably carried by K+ and were characterized by an early transient and a late persistent component. Extracellular application of arachidonic acid (50 microM) enhanced both components of the voltage-dependent K+ response by 15-29% (n > 20 cells). These effects were reversible and not observed when a low dose (50 microM) of indomethacin was present in the bath (n = 7 cells). We conclude that one or more of the arachidonic acid metabolites of the cyclooxygenase pathway might be involved in the modulation of outward currents in neocortical cells in culture.
Keywords
Animals
Arachidonic Acid/*pharmacology
Cerebral Cortex/cytology/*drug effects
Neurons/*drug effects
Potassium Channels/*drug effects
Rats
Rats, Wistar
Pubmed
Web of science
Create date
24/01/2008 14:17
Last modification date
20/08/2019 16:45