Laminar development of the mouse barrel cortex: effects of neurotoxins against monoamines

Details

Serval ID
serval:BIB_CACC60EA97DF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Laminar development of the mouse barrel cortex: effects of neurotoxins against monoamines
Journal
Experimental Brain Research
Author(s)
Osterheld-Haas  M. C., Hornung  J. P.
ISSN
0014-4819 (Print)
Publication state
Published
Issued date
07/1996
Volume
110
Number
2
Pages
183-95
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Abstract
The rodent somatosensory cortex is characterized by a unique cellular organization in the field of representation of the whiskers, called the barrelfield, which develops in layer IV during the 1st postnatal week in parallel with the establishment of the thalamo-cortical connections. This area is transiently densely innervated by serotonergic afferents during this period. Serotonin depletion delays the formation of barrels in the rat somatosensory cortex. However, no information is available to date on the time-course of the laminar differentiation of the cortex after monoaminergic depletion and the relative contribution of different monoaminergic inputs to this process. To address these issues, newborn mice were treated with selective neurotoxins (6-hydroxydopamine or 5,7-dihydroxytryptamine) at birth to destroy the catecholaminergic and monoaminergic cortical innervation, respectively. The parietal cortex of these animals was examined in Nissl-stained coronal sections prepared on different days of postnatal development (between P2 and P30). Compared with the controls, delayed growth and differentiation of the cortical layers II-IV were observed in the treated animals, most prominently between P2 and P16. From the 3rd postnatal week, no cytoarchitectonic difference could be detected. Although neonatal depletion of the cortical monoaminergic innervation does not affect the laminar organization of the adult mouse barrelfield, it significantly delays the time-course of development of several cortical layers. This delay generates a mismatch in the degree of maturation between cortical neurons and their afferents at a time when neuronal interactions are critical for the establishment of local circuitry.
Keywords
Afferent Pathways/growth & development Age Factors Animals Animals, Newborn Catecholamines/antagonists & inhibitors/pharmacology/*physiology Histocytochemistry Immunohistochemistry Mice Mice, Inbred Strains Neurons, Afferent/*physiology Serotonin/*physiology Serotonin Antagonists/pharmacology Somatosensory Cortex/anatomy & histology/*growth & development
Pubmed
Web of science
Create date
24/01/2008 15:22
Last modification date
20/08/2019 16:45
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