Lactobacillus supports Clostridiales to restrict gut colonization by multidrug-resistant Enterobacteriaceae.
Details
Serval ID
serval:BIB_CAA9228C8C73
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lactobacillus supports Clostridiales to restrict gut colonization by multidrug-resistant Enterobacteriaceae.
Journal
Nature communications
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
24/09/2022
Peer-reviewed
Oui
Volume
13
Number
1
Pages
5617
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
Publication Status: epublish
Publication Status: epublish
Abstract
Infections by multidrug-resistant Enterobacteriaceae (MRE) are life-threatening to patients. The intestinal microbiome protects against MRE colonization, but antibiotics cause collateral damage to commensals and open the way to colonization and subsequent infection. Despite the significance of this problem, the specific commensals and mechanisms that restrict MRE colonization remain largely unknown. Here, by performing a multi-omic prospective study of hospitalized patients combined with mice experiments, we find that Lactobacillus is key, though not sufficient, to restrict MRE gut colonization. Lactobacillus rhamnosus and murinus increase the levels of Clostridiales bacteria, which induces a hostile environment for MRE growth through increased butyrate levels and reduced nutrient sources. This mechanism of colonization resistance, an interaction between Lactobacillus spp. and Clostridiales involving cooperation between microbiota members, is conserved in mice and patients. These results stress the importance of exploiting microbiome interactions for developing effective probiotics that prevent infections in hospitalized patients.
Keywords
Animals, Anti-Bacterial Agents/pharmacology, Butyrates/pharmacology, Clostridiales, Enterobacteriaceae, Lactobacillus, Mice, Prospective Studies
Pubmed
Web of science
Open Access
Yes
Create date
03/10/2022 14:53
Last modification date
23/01/2024 8:34