Does glutamate image your thoughts?
Details
Serval ID
serval:BIB_CAA27ED9F62A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Does glutamate image your thoughts?
Journal
Trends in Neurosciences
ISSN
0166-2236 (Print)
Publication state
Published
Issued date
07/2002
Volume
25
Number
7
Pages
359-64
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review --- Old month value: Jul
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review --- Old month value: Jul
Abstract
Functional imaging methods exploit the relationship between neuronal activity, energy demand and cerebral blood flow to functionally map the brain. Despite the increasing use of these imaging tools in basic and clinical neuroscience, the neurobiological processes underlying the imaging signals remain unclear. Recently, interest has been focused on uncovering the signals that trigger the metabolic and vascular changes accompanying variations in neuronal activity. Advances in this field have demonstrated that release of the major excitatory neurotransmitter glutamate initiates diverse signaling processes between neurons and astrocytes, and that this signaling could be crucial for the occurrence of brain imaging signals. In this article we review the hypothesis that glutamate represents a common trigger for both neurometabolic and neurovascular coupling.
Keywords
Animals
Astrocytes/cytology/*metabolism
Brain/*physiology/*radionuclide imaging
Cerebrovascular Circulation/*physiology
Cognition/physiology
Energy Metabolism/*physiology
Glutamic Acid/*metabolism
Humans
Magnetic Resonance Imaging
Presynaptic Terminals/*metabolism/ultrastructure
Synaptic Transmission/*physiology
Tomography, Emission-Computed
Pubmed
Web of science
Create date
24/01/2008 14:17
Last modification date
20/08/2019 16:45