Bundle-Specific Axon Diameter Index as a New Contrast to Differentiate White Matter Tracts.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_CAA1D94160F7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Bundle-Specific Axon Diameter Index as a New Contrast to Differentiate White Matter Tracts.
Journal
Frontiers in neuroscience
Author(s)
Barakovic M., Girard G., Schiavi S., Romascano D., Descoteaux M., Granziera C., Jones D.K., Innocenti G.M., Thiran J.P., Daducci A.
ISSN
1662-4548 (Print)
ISSN-L
1662-453X
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
15
Pages
646034
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
In the central nervous system of primates, several pathways are characterized by different spectra of axon diameters. In vivo methods, based on diffusion-weighted magnetic resonance imaging, can provide axon diameter index estimates non-invasively. However, such methods report voxel-wise estimates, which vary from voxel-to-voxel for the same white matter bundle due to partial volume contributions from other pathways having different microstructure properties. Here, we propose a novel microstructure-informed tractography approach, COMMIT <sub>AxSize</sub> , to resolve axon diameter index estimates at the streamline level, thus making the estimates invariant along trajectories. Compared to previously proposed voxel-wise methods, our formulation allows the estimation of a distinct axon diameter index value for each streamline, directly, furnishing a complementary measure to the existing calculation of the mean value along the bundle. We demonstrate the favourable performance of our approach comparing our estimates with existing histologically-derived measurements performed in the corpus callosum and the posterior limb of the internal capsule. Overall, our method provides a more robust estimation of the axon diameter index of pathways by jointly estimating the microstructure properties of the tissue and the macroscopic organisation of the white matter connectivity.
Keywords
diffusion MRI, human brain, microstructure, microstructure informed tractography, tractography, white-matter axon signature
Pubmed
Web of science
Open Access
Yes
Create date
12/07/2021 12:02
Last modification date
08/08/2024 7:40
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