Trends in congenital anomalies in Europe from 1980 to 2012.

Details

Serval ID
serval:BIB_CA5D91F2E330
Type
Article: article from journal or magazin.
Collection
Publications
Title
Trends in congenital anomalies in Europe from 1980 to 2012.
Journal
PloS one
Author(s)
Morris J.K., Springett A.L., Greenlees R., Loane M., Addor M.C., Arriola L., Barisic I., Bergman JEH, Csaky-Szunyogh M., Dias C., Draper E.S., Garne E., Gatt M., Khoshnood B., Klungsoyr K., Lynch C., McDonnell R., Nelen V., Neville A.J., O'Mahony M., Pierini A., Queisser-Luft A., Randrianaivo H., Rankin J., Rissmann A., Kurinczuk J., Tucker D., Verellen-Dumoulin C., Wellesley D., Dolk H.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
13
Number
4
Pages
e0194986
Language
english
Notes
Publication types: Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Surveillance of congenital anomalies is important to identify potential teratogens.
This study analysed the prevalence of 61 congenital anomaly subgroups (excluding chromosomal) in 25 population-based EUROCAT registries (1980-2012). Live births, fetal deaths and terminations of pregnancy for fetal anomaly were analysed with multilevel random-effects Poisson regression models.
Seventeen anomaly subgroups had statistically significant trends from 2003-2012; 12 increasing and 5 decreasing.
The annual increasing prevalence of severe congenital heart defects, single ventricle, atrioventricular septal defects and tetralogy of Fallot of 1.4% (95% CI: 0.7% to 2.0%), 4.6% (1.0% to 8.2%), 3.4% (1.3% to 5.5%) and 4.1% (2.4% to 5.7%) respectively may reflect increases in maternal obesity and diabetes (known risk factors). The increased prevalence of cystic adenomatous malformation of the lung [6.5% (3.5% to 9.4%)] and decreased prevalence of limb reduction defects [-2.8% (-4.2% to -1.5%)] are unexplained. For renal dysplasia and maternal infections, increasing trends may be explained by increased screening, and deceases in patent ductus arteriosus at term and increases in craniosynostosis, by improved follow up period after birth and improved diagnosis. For oesophageal atresia, duodenal atresia/stenosis and ano-rectal atresia/stenosis recent changes in prevalence appeared incidental when compared with larger long term fluctuations. For microcephaly and congenital hydronephrosis trends could not be interpreted due to discrepancies in diagnostic criteria. The trends for club foot and syndactyly disappeared once registries with disparate results were excluded. No decrease in neural tube defects was detected, despite efforts at prevention through folic acid supplementation.
Keywords
Congenital Abnormalities/diagnosis, Congenital Abnormalities/epidemiology, Congenital Abnormalities/etiology, Congenital Abnormalities/history, Europe/epidemiology, Female, History, 20th Century, History, 21st Century, Humans, Male, Population Surveillance, Pregnancy, Prevalence, Registries
Pubmed
Web of science
Open Access
Yes
Create date
14/04/2018 11:14
Last modification date
20/08/2019 16:45
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