Corticobasal degeneration. A unique pattern of regional cortical oxygen hypometabolism and striatal fluorodopa uptake demonstrated by positron emission tomography.

Details

Serval ID
serval:BIB_CA36BFA8740A
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Corticobasal degeneration. A unique pattern of regional cortical oxygen hypometabolism and striatal fluorodopa uptake demonstrated by positron emission tomography.
Journal
Brain
Author(s)
Sawle G.V., Brooks D.J., Marsden C.D., Frackowiak R.S.
ISSN
0006-8950 (Print)
ISSN-L
0006-8950
Publication state
Published
Issued date
1991
Volume
114 ( Pt 1B)
Pages
541-556
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Corticobasal degeneration presents with an asymmetric akinetic-rigid syndrome, apraxia and combinations of supranuclear gaze palsy, myoclonus, and an alien limb. Six patients aged 59-77 yrs, diagnosed on clinical criteria as having corticobasal degeneration, have been studied with positron emission tomography using tracers of dopamine storage capacity and oxygen metabolism. Striatal 18F-6-fluorodopa uptake was reduced in an asymmetric pattern, caudate and putamen being involved in all cases. Uptake into medial frontal cortex was also impaired. Regional cortical oxygen metabolism was most significantly depressed in the superior and posterior temporal, inferior parietal, and occipital associated cortices. Within the frontal lobe, the hypometabolism was chiefly posterior. This unique combination of regional hypometabolism and disruption of the nigrostriatal system is discussed in relation to the clinical features of the disease and is compared with reported findings in other disorders of cognition and movement.
Keywords
Aged, Animals, Apraxias/metabolism, Apraxias/physiopathology, Brain Diseases/metabolism, Brain Diseases/radionuclide imaging, Cerebral Cortex/metabolism, Cerebral Cortex/radionuclide imaging, Corpus Striatum/metabolism, Corpus Striatum/radionuclide imaging, Dihydroxyphenylalanine/metabolism, Extremities/physiopathology, Female, Fluorine Radioisotopes/diagnostic use, Humans, Male, Middle Aged, Muscle Rigidity/metabolism, Myoclonus/metabolism, Oxygen/metabolism, Supranuclear Palsy, Progressive/metabolism, Syndrome, Tomography, Emission-Computed
Pubmed
Web of science
Create date
06/10/2011 19:11
Last modification date
20/08/2019 15:45
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