Intraoperative Photoactivated Chromophore for Infectious Keratitis-Corneal Cross-Linking (PACK-CXL) During Penetrating Keratoplasty for the Management of Fungal Keratitis in an Immunocompromised Patient.

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Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_CA33F1722772
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Intraoperative Photoactivated Chromophore for Infectious Keratitis-Corneal Cross-Linking (PACK-CXL) During Penetrating Keratoplasty for the Management of Fungal Keratitis in an Immunocompromised Patient.
Journal
Ophthalmology and therapy
Author(s)
Mikropoulos D.G., Kymionis G.D., Voulgari N., Kaisari E., Nikolakopoulos K.A., Katsanos A., Konstas A.G.
ISSN
2193-8245 (Print)
Publication state
Published
Issued date
09/2019
Peer-reviewed
Oui
Volume
8
Number
3
Pages
491-495
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To present a novel intraoperative application of photoactivated chromophore for infectious keratitis-corneal cross-linking (PACK-CXL) in the management of post-penetrating keratoplasty (PKP) multiresistant fungal keratitis in a patient with irradiation-related local immunosuppression.
A 62-year-old female underwent uneventful PKP for the management of post-irradiation actinic keratopathy. Three months postoperatively, she presented with a diffuse corneal melting abscess that was infiltrating the donor-recipient junction. Despite intensive antibiotic and antifungal therapy, corneal melting progressed to graft perforation. A repeat PKP combined with intraoperative PACK-CXL was performed. PACK-CXL was applied initially on the infected graft, involving the corneoscleral rim and then following placement of the donor button. No intra- or postoperative graft-related complications were encountered. No signs of infection were noted, and the graft remained clear during the 9-month follow-up period.
Intraoperative PACK-CXL combined with PKP appears to be a safe and effective technique for the management of post-PKP resistant fungal keratitis.
Keywords
Corneal cross-linking, Fungal keratitis, PACK-CXL, Penetrating keratoplasty
Pubmed
Open Access
Yes
Create date
21/07/2019 16:41
Last modification date
12/01/2022 8:13
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