Investigators' sense of failure thwarted transparency in clinical trials discontinued for poor recruitment.

Details

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_CA197DF2BA86
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Investigators' sense of failure thwarted transparency in clinical trials discontinued for poor recruitment.
Journal
Journal of clinical epidemiology
Author(s)
Satalkar P., McLennan S., Elger B.S., von Elm E., Matthias B.
ISSN
1878-5921 (Electronic)
ISSN-L
0895-4356
Publication state
Published
Issued date
05/2022
Peer-reviewed
Oui
Volume
145
Pages
136-143
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
When a randomized clinical trial (RCT) prematurely discontinues, it is essential that stakeholders do the right thing to ensure that lessons can be learnt and trust in clinical research is maintained. There is, however, a lack of evidence exploring this issue. This study aimed to examine clinical trial stakeholders' practices following trial discontinuation due to poor participant recruitment and their views on implications of such discontinuation.
Individual semi-structured qualitative interviews were conducted with 49 clinical trial stakeholders from Switzerland (n = 39), Germany (n = 9) and Canada (n = 1) between August 2015 and November 2016.
After interviews with 49 clinical trial stakeholders (75% male presenting), it was found that stakeholders were aware of the risks of premature trial discontinuation wasting limited resources, adversely impacting scientific evidence, and having negative personal and professional implications. However, barriers continue to undermine transparency regarding trial discontinuation in practice, with it being reported that most investigators of discontinued trials are failing to notify stakeholders or publishing their results. Investigators sense of failure and associated negative emotions were identified as a key reason why investigators are not more transparent following discontinuation.
The decision to notify stakeholders and publish results of a discontinued clinical trial should not rest solely on individual investigators but come from a systemic approach. However, until health research proactively requires the dissemination of results of all clinical trials, much will rest on individual investigators being motivated to do the right thing. Support programs might be helpful for investigators involved in discontinued trials and promote transparency and learning lessons.
Keywords
Female, Germany, Humans, Male, Patient Selection, Publishing, Research Personnel, Risk Factors, Implications, Participant recruitment, Qualitative research, Randomized controlled trials, Transparency, Trial discontinuation, Trial stakeholders
Pubmed
Web of science
Open Access
Yes
Create date
12/02/2022 15:48
Last modification date
16/09/2023 7:15
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