Advances in the understanding and management of angioimmunoblastic T-cell lymphoma.

Details

Serval ID
serval:BIB_C9590EBDAC8B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Advances in the understanding and management of angioimmunoblastic T-cell lymphoma.
Journal
British Journal of Haematology
Author(s)
de Leval L., Gisselbrecht C., Gaulard P.
ISSN
1365-2141 (Electronic)
ISSN-L
0007-1048
Publication state
Published
Issued date
2010
Volume
148
Number
5
Pages
673-689
Language
english
Notes
Publication types: Journal Article ; Review
Abstract
Angioimmunoblastic T-cell lymphoma (AITL) is a distinct peripheral T-cell lymphoma (PTCL) entity with peculiar clinical and pathological features. The recent identification of follicular helper T (T(FH)) cell as the cell of origin of this neoplasm represents a major step in our understanding of the pathobiological characteristics of the disease and should, in the future, clarify the diagnostic criteria for AITL and help to delineate its spectrum, especially from PTCL, not otherwise specified (PTCL, NOS). Deciphering the pathogenesis of the disease is needed to identify targets for new therapies that are expected to improve the poor outcome of AITL patients, when treated with conventional chemotherapy regimens. In this respect, efforts will be needed to evaluate promising innovative therapies in prospective clinical trials.
Keywords
Antineoplastic Agents/administration & dosage, Cytogenetics, Diagnosis, Differential, Humans, Immunophenotyping, Lymphoma, T-Cell, Peripheral/diagnosis, Lymphoma, T-Cell, Peripheral/genetics, Lymphoma, T-Cell, Peripheral/</QualifierName> <QualifierName MajorTopicYN="N">, Prognosis, T-Lymphocytes, Helper-Inducer/metabolism
Pubmed
Open Access
Yes
Create date
22/10/2010 9:52
Last modification date
20/08/2019 15:44
Usage data