Comment gérer l’effet rebond à l’arrêt du dénosumab et éviter les fractures vertébrales multiples ? [How to manage the rebound effect at denosumab discontinuation and avoid multiple vertebral fractures?]

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State: Public
Version: author
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Serval ID
serval:BIB_C93F3BDC4548
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Comment gérer l’effet rebond à l’arrêt du dénosumab et éviter les fractures vertébrales multiples ? [How to manage the rebound effect at denosumab discontinuation and avoid multiple vertebral fractures?]
Journal
Revue medicale suisse
Author(s)
Gonzalez Rodriguez E., Lamy O., Aubry-Rozier B., Stoll D., Uebelhart B.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
17/04/2019
Peer-reviewed
Oui
Volume
15
Number
647
Pages
831-835
Language
french
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Denosumab discontinuation is associated with a severe rebound effect combining elevation of bone remodeling markers for two years and loss of the gained bone density. In the absence of a potent bisphosphonate prescription at denosumab discontinuation, multiple vertebral fractures are frequent. The median number of vertebral fractures is 5, within 7 to 20 months (median 11) after the last denosumab injection. A potent bisphosphonate prescribed at denosumab discontinuation may reduce this risk. This strategy requires close monitoring of bone remodeling markers and adjustment of treatment if bone remodeling is not controlled.
Keywords
Bone Density Conservation Agents/administration & dosage, Bone Density Conservation Agents/adverse effects, Bone Remodeling, Denosumab/administration & dosage, Denosumab/adverse effects, Diphosphonates, Humans, Osteoporosis, Postmenopausal/drug therapy, Spinal Fractures/chemically induced, Spinal Fractures/prevention & control
Pubmed
Create date
28/04/2019 14:12
Last modification date
23/01/2020 6:19
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