Expression of dual angiogenic/neurogenic growth factors in human primary brain tumors.

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Serval ID
serval:BIB_C93B93755B42
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Expression of dual angiogenic/neurogenic growth factors in human primary brain tumors.
Journal
Journal of Neuro-oncology
Author(s)
Clemessy M., Janzer R.C., Lhermitte B., Gasc J.M., Juillerat-Jeanneret L.
ISSN
1573-7373 (Electronic)
ISSN-L
0167-594X
Publication state
Published
Issued date
2012
Volume
107
Number
1
Pages
29-36
Language
english
Notes
Dédié à Robert-Charles Janzer, de l'Institut universitaire de pathologie à Lausanne, décédé soudainement le 27 septembre 2010
Abstract
Brain tumors, benign or malignant, are characterized by a very high degree of vascularization. Recent accumulating evidence suggests that during development the neuronal wiring follows the same routes as the vasculature and that these two systems may share some of the same factors for guidance. Thus, expression of dual angiogenic/neurogenic growth factors was evaluated by in situ hybridization in human primary brain tumors of three different types, i.e., astrocytomas, oligodendrogliomas, and ependymomas, of increasing grades, in relation with the grade and type of the tumor. For this evaluation we selected vascular endothelial growth factor (VEGF-A) and its receptors VEGF-R1 and VEGF-R2 and the neuropilins 1 and 2 (NRP-1 and NRP-2), which have proangiogenic properties, platelet-derived growth factor (PDGF) receptor-beta (PDGF-Rβ), which is required for the functional maturation of blood vessels, the ephrins and their Eph receptors, angiotensinogen (AGT) and thrombospondin-2 (TSP-2), which have potential antiangiogenic properties, and netrin-1 (Net-1), which regulates vascular architecture. We show that the expression of the VEGF-NRP system, PDGF-Rβ, TSP-2, AGT, and Net-1 are differentially regulated, either increased or decreased, in relation with the type and grade of the tumor, whereas regulation of the ephrinB system does not seem to be relevant in these human brain tumors.
Pubmed
Web of science
Open Access
Yes
Create date
17/02/2012 12:26
Last modification date
01/10/2019 7:19
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