Some children are inactive on weekends but active on weekdays. Correlates of such behavior remain to be clarified. We assessed school, out-of-school and family correlates of compliance with physical activity (PA) recommendations during weekdays among weekend non-compliant youth in Switzerland. Cross-sectional data collected in 2013-2015 from the SOPHYA study. PA was objectively measured during one week using waist-worn accelerometers. Compliance with PA recommendations (≥ 60 min/day of moderate-to-vigorous PA) was assessed separately for weekend and weekdays. Data on school sport, transport to school, sports club participation, household income, parent's PA and education were collected by phone interview and questionnaires. Data from 540 youth (316 girls) aged 6-16 years were available for analysis. Participants who were compliant to recommendations during weekdays were more frequently boys (50.3% vs. 31.4%, p < 0.001), more often participated in sports club (73.3% vs. 64.3%, p = 0.024), and were more prone to adopt active transport to school (75.8% vs. 62.0%, p = 0.001) than non-compliers. Multivariable adjustment showed male gender [odds ratio and (95% confidence interval): 4.30 (2.71-6.81)], sports club participation [1.91 (1.21-3.02)], and PA-active parent [1.98 (1.20-3.28)] were significantly associated with weekday compliance. Being a male, a sports club participant and having a physically active parent significantly increase compliance with PA recommendations during weekdays among Swiss youth who are inactive on weekends.