Hypertrophic response of human skeletal muscle to strength training in hypoxia and normoxia.

Details

Serval ID
serval:BIB_C91D296CC50E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Hypertrophic response of human skeletal muscle to strength training in hypoxia and normoxia.
Journal
European Journal of Applied Physiology and Occupational Physiology
Author(s)
Narici M.V., Kayser B.
ISSN
1439-6319
ISSN-L
0301-5548
Publication state
Published
Issued date
1995
Volume
70
Number
3
Pages
213-219
Language
english
Abstract
The purpose of this study was to test the hypothesis that work-induced skeletal muscle hypertrophy may be reduced by training in chronic hypobaric hypoxia compared to normoxia. Five healthy males [mean age 34.4 (SEM 2.2) years] performed strength training of the elbow flexors for 1 month, at altitude (A) (5050 m) and with the same absolute loads at sea level (SL), 8 months later. The EF cross-sectional area (CSA), determined at mid-arm by nuclear magnetic resonance imaging, increased by 11.3 (SEM 3.7)% (P < 0.05) at A and 17.7 (SEM 4.5)% (P < 0.05) at SL. Isometric maximal voluntary contraction (MVC) increased by 9.5 (SEM 2.6)% (P < 0.05) at A and 13.6 (SEM 2.4)% (P < 0.05) at SL. The CSA and MVC changes in A were significantly smaller than at SL (P < 0.05). Muscle specific tension did not change in either condition. No changes in muscle plus bone or MVC of the untrained, controlateral arm were observed. Thus, although there was no indication of muscle wasting at A, the hypertrophic response of skeletal muscle when trained in chronic hypoxia seemed to be significantly lower than that produced in normoxia. This effect could have arisen either from a direct depression of protein synthesis and/or hormonal changes provoked by hypoxia.
Keywords
Adult, Altitude, Anoxia/metabolism, Arm/anatomy & histology, Arm/physiology, Atmospheric Pressure, Elbow Joint/physiology, Exercise/physiology, Humans, Magnetic Resonance Spectroscopy, Male, Muscle Proteins/biosynthesis, Muscle, Skeletal/anatomy & histology, Muscle, Skeletal/metabolism, Time Factors
Pubmed
Web of science
Create date
19/09/2013 10:14
Last modification date
20/08/2019 15:44
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