Diversity and evolution of an abundant ICEclc family of integrative and conjugative elements in Pseudomonas aeruginosa.
Details
Serval ID
serval:BIB_C8BBFFC92257
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Diversity and evolution of an abundant ICEclc family of integrative and conjugative elements in Pseudomonas aeruginosa.
Journal
mSphere
ISSN
2379-5042 (Electronic)
ISSN-L
2379-5042
Publication state
Published
Issued date
20/12/2023
Peer-reviewed
Oui
Volume
8
Number
6
Pages
e0051723
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Microbial populations swiftly adapt to changing environments through horizontal gene transfer. While the mechanisms of gene transfer are well known, the impact of environmental conditions on the selection of transferred gene functions remains less clear. We investigated ICEs, specifically the ICEclc-type, in Pseudomonas aeruginosa clinical isolates. Our findings revealed co-evolution between ICEs and their hosts, with ICE transfers occurring within strains. Gene functions carried by ICEs are positively selected, including potential virulence factors and heavy metal resistance. Comparison to publicly available P. aeruginosa genomes unveiled widespread antibiotic-resistance determinants within ICEclc clades. Thus, the ubiquitous ICEclc family significantly contributes to P. aeruginosa's adaptation and fitness in diverse environments.
Keywords
Pseudomonas aeruginosa/genetics, Gene Transfer, Horizontal, Pseudomonas aeruginosa, adaptation, bacterial evolution, clc element, horizontal gene transfer, integrative and conjugative element
Pubmed
Web of science
Open Access
Yes
Create date
06/11/2023 14:17
Last modification date
11/01/2024 8:14