Development and selection of Valpha l4i NKT cells.
Details
Serval ID
serval:BIB_C888E109BDFD
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Development and selection of Valpha l4i NKT cells.
Journal
Current topics in microbiology and immunology
ISSN
0070-217X
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
314
Pages
195-212
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Valpha14 invariant natural killer T (Valpha14i NKT) cells are a unique lineage of mouse T cells that share properties with both NK cells and memory T cells. Valpha14i NKT cells recognize CDld-associated glycolipids via a semi-invariant T cell receptor (TCR) composed of an invariant Valpha14-Jalpha 18 chain paired preferentially with a restricted set of TCRbeta chains. During development in the thymus, rare CD4+ CD8+ (DP) cortical thymocytes that successfully rearrange the semi-invariant TCR are directed to the Valpha14i NKT cell lineage via interactions with CD d-associated endogenous glycolipids expressed by other DP thymocytes. As they mature, Valphal4i NKT lineage cells upregulate activation markers such as CD44 and subsequently express NK-related molecules such as NKI.1 and members of the Ly-49 inhibitory receptor family. The developmental program of Valpha l4i NKT cells is critically regulated by a number of signaling cues that have little or no effect on conventional T cell development, such as the Fyn/SAP/SLAM pathway, NFkappaB and T-bet transcription factors, and the cytokine IL-15. The unique developmental requirements of Valphal4i NKT cells may represent a paradigm for other unconventional T cell subsets that are positively selected by agonist ligands expressed on hematopoietic cells.
Keywords
Animals, Cell Differentiation/genetics, Cell Differentiation/immunology, Humans, Killer Cells, Natural/cytology, Killer Cells, Natural/immunology, Mice, Signal Transduction, T-Lymphocyte Subsets/cytology, T-Lymphocyte Subsets/immunology
Pubmed
Web of science
Create date
09/02/2010 14:55
Last modification date
20/08/2019 16:43