Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy.

Details

Serval ID
serval:BIB_C8315E77A999
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy.
Journal
Neurology
Author(s)
Katz-Brull R., Lenkinski R.E., Du Pasquier R.A., Koralnik I.J.
ISSN
1526-632X (Electronic)
ISSN-L
0028-3878
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
63
Number
5
Pages
897-900
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Abstract
MRI, 1H-MR spectroscopy, immunologic, and virologic studies were performed in search of prognostic factors of disease evolution in patients with progressive multifocal leukoencephalopathy (PML). Acute lesions of PML survivors showed twofold higher standard score of the ratio of myoinositol (a glial marker) to creatine compared with lesions in patients whose disease progressed. Concomitantly, JC virus-specific cytotoxic T lymphocytes were only detected in the blood of PML survivors. These results suggest that inflammation limits disease progression.
Keywords
Adult, Aspartic Acid/analogs & derivatives, Aspartic Acid/analysis, Cerebellum/metabolism, Cerebral Cortex/metabolism, Choline/analysis, Creatine/analysis, Disease Progression, Female, HIV Infections/complications, Humans, Inositol/analysis, JC Virus/immunology, Leukoencephalopathy, Progressive Multifocal/blood, Leukoencephalopathy, Progressive Multifocal/immunology, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Male, Middle Aged, Survivors, T-Cell Antigen Receptor Specificity, T-Lymphocytes, Cytotoxic/immunology
Pubmed
Web of science
Create date
25/01/2008 14:56
Last modification date
20/08/2019 15:43
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