Abscopal effect in a patient with malignant pleural mesothelioma treated with palliative radiotherapy and pembrolizumab.

Details

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_C82F89BA6EDB
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Abscopal effect in a patient with malignant pleural mesothelioma treated with palliative radiotherapy and pembrolizumab.
Journal
Clinical and translational radiation oncology
Author(s)
Mampuya W.A., Bouchaab H., Schaefer N., Kinj R., La Rosa S., Letovanec I., Ozsahin M., Bourhis J., Coukos G., Peters S., Herrera F.G.
ISSN
2405-6308 (Electronic)
ISSN-L
2405-6308
Publication state
Published
Issued date
03/2021
Peer-reviewed
Oui
Volume
27
Pages
85-88
Language
english
Notes
Publication types: Case Reports
Publication Status: epublish
Abstract
The abscopal effect describes the ability of locally administered radiotherapy to induce systemic antitumor effects. Although mentioned for the first time in the 1950s, records of abscopal effects, considered to be immune-mediated, are scarce with radiotherapy alone. However, with the continued development and use of immunotherapy, reports on the abscopal effect have become increasingly frequent during the last decade. Here, we report a patient with advanced malignant pleural mesothelioma who had progressive disease while on the anti-PDL1 inhibitor pembrolizumab and showed an abscopal response after palliative radiotherapy.
Keywords
Abscopal effect, Checkpoint inhibitors, Immunotherapy, Malignant pleural mesothelioma, Radiotherapy
Pubmed
Web of science
Open Access
Yes
Create date
01/02/2021 19:02
Last modification date
08/05/2021 6:32
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