Chronic Migraine Preventive Treatment by Prefrontal-Occipital Transcranial Direct Current Stimulation (tDCS): A Proof-of-Concept Study on the Effect of Psychiatric Comorbidities.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_C82A71DDCC2A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Chronic Migraine Preventive Treatment by Prefrontal-Occipital Transcranial Direct Current Stimulation (tDCS): A Proof-of-Concept Study on the Effect of Psychiatric Comorbidities.
Journal
Frontiers in neurology
Author(s)
Mastria G., Viganò A., Corrado A., Mancini V., Pirillo C., Badini S., Petolicchio B., Toscano M., Altieri M., Delle Chiaie R., Di Piero V.
ISSN
1664-2295 (Print)
ISSN-L
1664-2295
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
12
Pages
654900
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Chronic migraine (CM) is often complicated by medication overuse headache (MOH) and psychiatric comorbidities that may influence the clinical outcome. This study aimed to investigate the relationship between psychiatric comorbidities and the effect of transcranial direct current stimulation (tDCS) in patients with CM with or without MOH. We recruited 16 consecutive CM patients who had an unsatisfactory response to at least three pharmacological preventive therapies. They were treated with anodal right-prefrontal and cathodal occipital tDCS (intensity: 2 mA, time: 20 min) three times per week for 4 weeks. All patients underwent a psychopathological assessment before and after treatment, and five of them were diagnosed with bipolar disorder (BD). After treatment, all the patients showed a significant decrease of severe and overall headache days per month. Despite having a higher migraine burden at baseline, patients with CM and BD showed a significantly greater reduction of severe headaches and psychiatric symptoms. Overall, tDCS seems to be effective in the treatment of CM patients with a poor response to different classes of pharmacological therapies, whereas BD status positively influences the response of migraineurs to tDCS.
Keywords
bipolar disorder, cerebellar stimulation, dorsolateral prefrontal cortex stimulation, migraine, migraine overuse headache, occipital cortex stimulation, tDCS
Pubmed
Web of science
Open Access
Yes
Create date
11/06/2021 17:17
Last modification date
08/08/2024 6:40
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