Neural responses associated with cue evoked emotional states and heroin in opiate addicts.
Details
Serval ID
serval:BIB_C823C1BDCDED
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Neural responses associated with cue evoked emotional states and heroin in opiate addicts.
Journal
Drug and Alcohol Dependence
ISSN
0376-8716 (Print)
ISSN-L
0376-8716
Publication state
Published
Issued date
2000
Volume
60
Number
2
Pages
207-216
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Ten male opiate addicts, who were current heroin injectors, underwent positron emission tomographic (PET) scanning during exposure to a sequence of six alternating drug related and neutral video cues, on two occasions. After the second scan, each subject received heroin or placebo using a randomised single-blind procedure. This design allowed the investigation of patterns of brain activity during a range of self-reported cue evoked emotional states, both in the presence and absence of heroin. Self-reports of 'urge to use' correlated strongly with increased regional blood flow (rCBF) in the inferior frontal and orbitofrontal cortex target regions of the mesolimbic dopaminergic system, implicated in conditioning and reward. 'Urge to use' was also associated with highly significant increased rCBF in the right pre-cuneus, an area associated with episodic memory retrieval, and in the left insula, implicated in the processing of the emotional components of stimuli. Self-reports of feeling 'high' correlated with rCBF activation in the hippocampus, an area relevant to the acquisition of stimulus-associated reinforcement.
Keywords
Adult, Analysis of Variance, Behavior, Addictive/psychology, Behavior, Addictive/radionuclide imaging, Brain/blood supply, Cues, Heroin, Humans, Linear Models, Male, Narcotics, Opioid-Related Disorders/psychology, Opioid-Related Disorders/radionuclide imaging, Tomography, Emission-Computed
Pubmed
Web of science
Create date
12/09/2011 19:48
Last modification date
20/08/2019 15:43