Mobilizing and evaluating anticancer T cells: pitfalls and solutions.

Details

Serval ID
serval:BIB_C7F99ECA59E4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Mobilizing and evaluating anticancer T cells: pitfalls and solutions.
Journal
Expert Review of Vaccines
Author(s)
Robert-Tissot C., Nguyen L.T., Ohashi P.S., Speiser D.E.
ISSN
1744-8395 (Electronic)
ISSN-L
1476-0584
Publication state
Published
Issued date
2013
Volume
12
Number
11
Pages
1325-1340
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublishReview
Abstract
Immunotherapy is a promising means to fight cancer, prompting a steady increase in clinical trials and correlative laboratory studies in this field. As antitumor T cells play central roles in immunity against malignant diseases, most immunotherapeutic protocols aim to induce and/or strengthen their function. Various treatment strategies have elicited encouraging clinical responses; however, major challenges have been uncovered that should be addressed in order to fully exploit the potential of immunotherapy. Here, we outline pitfalls for the mobilization of antitumor T cells and offer solutions to improve their therapeutic efficacy. We provide a critical perspective on the main methodologies used to characterize T-cell responses to cancer therapies, with a focus on discrepancies between T-cell attributes measured in vitro and protective responses in vivo. This review altogether provides recommendations to optimize the design of future clinical trials and highlights important considerations for the proficient analysis of clinical specimens available for research.
Pubmed
Web of science
Create date
17/11/2013 19:18
Last modification date
20/08/2019 16:43
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