Point-of-care measurement of serum creatinine in the intensive care unit.

Details

Serval ID
serval:BIB_C7F4B415467A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Point-of-care measurement of serum creatinine in the intensive care unit.
Journal
Renal Failure
Author(s)
Calzavacca P., Tee A., Licari E., Schneider A.G., Bellomo R.
ISSN
1525-6049 (Electronic)
ISSN-L
0886-022X
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
34
Number
1
Pages
13-18
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
OBJECTIVE: To test the precision and limits of agreement of point-of-care testing (POCT)-based measurement of serum creatinine (Cr) in critically ill patients.
METHODS: We studied 250 paired blood samples from 82 critically ill patients from a general intensive care unit by simultaneous POCT and central laboratory testing (Jaffé method). Correlation, precision, bias, and limits of agreement were assessed. Possible confounders for interference of noncreatinine chromogens were evaluated by multivariate linear regression analysis.
RESULTS: The mean difference in serum Cr measured by central laboratory and POCT was +9.6 μmol/L (95% limits of agreement: -11.2 to +30.4 μmol/L). The mean percentage difference between the two techniques was 8.7% (95% limits of agreement -7.8% to +25.1%). On multivariate regression, the difference in serum Cr was increased with greater hemoglobin and lactate levels but decreased with greater bilirubin, albumin, and calcium levels.
CONCLUSIONS: Compared with the central laboratory testing, POCT-based measurement of serum Cr in critically ill patients carried a small negative bias. This difference appeared affected by the blood levels of biochemical variables known to affect the Jaffé method. POCT-based Cr measurement appears sufficiently accurate for clinical use.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Creatinine/blood, Critical Illness, Female, Humans, Intensive Care Units, Male, Middle Aged, Point-of-Care Systems, Prospective Studies, Reproducibility of Results, Young Adult
Pubmed
Web of science
Create date
26/11/2014 23:09
Last modification date
03/03/2018 21:20
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