Genome-wide profiling of blood pressure in adults and children.

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State: Public
Version: author
Serval ID
serval:BIB_C7C922C9908D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genome-wide profiling of blood pressure in adults and children.
Journal
Hypertension
Author(s)
Taal H.R., Verwoert G.C., Demirkan A., Janssens A.C., Rice K., Ehret G., Smith A.V., Verhaaren B.F., Witteman J.C., Hofman A., Vernooij M.W., Uitterlinden A.G., Rivadeneira F., Ikram M.A., Levy D., van der Heijden A.J., Aging Research in Genome Epidemiology, Jaddoe V.W., Jaddoe V.W., van Duijn C.M.
Working group(s)
Cohort for Heart, Early Genetics, Lifecourse Epidemiology consortia
ISSN
1524-4563 (Electronic)
ISSN-L
0194-911X
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
59
Number
2
Pages
241-247
Language
english
Abstract
Hypertension is an important determinant of cardiovascular morbidity and mortality and has a substantial heritability, which is likely of polygenic origin. The aim of this study was to assess to what extent multiple common genetic variants contribute to blood pressure regulation in both adults and children and to assess overlap in variants between different age groups, using genome-wide profiling. Single nucleotide polymorphism sets were defined based on a meta-analysis of genome-wide association studies on systolic blood pressure and diastolic blood pressure performed by the Cohort for Heart and Aging Research in Genome Epidemiology (n=29 136), using different P value thresholds for selecting single nucleotide polymorphisms. Subsequently, genetic risk scores for systolic blood pressure and diastolic blood pressure were calculated in an independent adult population (n=2072) and a child population (n=1034). The explained variance of the genetic risk scores was evaluated using linear regression models, including sex, age, and body mass index. Genetic risk scores, including also many nongenome-wide significant single nucleotide polymorphisms, explained more of the variance than scores based only on very significant single nucleotide polymorphisms in adults and children. Genetic risk scores significantly explained ≤1.2% (P=9.6*10(-8)) of the variance in adult systolic blood pressure and 0.8% (P=0.004) in children. For diastolic blood pressure, the variance explained was similar in adults and children (1.7% [P=8.9*10(-10)] and 1.4% [P=3.3*10(-5)], respectively). These findings suggest the presence of many genetic loci with small effects on blood pressure regulation both in adults and children, indicating also a (partly) common polygenic regulation of blood pressure throughout different periods of life.
Pubmed
Web of science
Open Access
Yes
Create date
20/03/2012 15:37
Last modification date
20/08/2019 16:43
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