Physical inactivity and obesity underlie the insulin resistance of aging.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_C7BCD5EE45C1
Type
Article: article from journal or magazin.
Collection
Publications
Title
Physical inactivity and obesity underlie the insulin resistance of aging.
Journal
Diabetes Care
Author(s)
Amati F., Dubé J.J., Coen P.M., Stefanovic-Racic M., Toledo F.G., Goodpaster B.H.
ISSN
1935-5548 (Electronic)
ISSN-L
0149-5992
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
32
Number
8
Pages
1547-1549
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural Publication
Abstract
OBJECTIVE Age-associated insulin resistance may underlie the higher prevalence of type 2 diabetes in older adults. We examined a corollary hypothesis that obesity and level of chronic physical inactivity are the true causes for this ostensible effect of aging on insulin resistance. RESEARCH DESIGN AND METHODS We compared insulin sensitivity in 7 younger endurance-trained athletes, 12 older athletes, 11 younger normal-weight subjects, 10 older normal-weight subjects, 15 younger obese subjects, and 15 older obese subjects using a glucose clamp. The nonathletes were sedentary. RESULTS Insulin sensitivity was not different in younger endurance-trained athletes versus older athletes, in younger normal-weight subjects versus older normal-weight subjects, or in younger obese subjects versus older obese subjects. Regardless of age, athletes were more insulin sensitive than normal-weight sedentary subjects, who in turn were more insulin sensitive than obese subjects. CONCLUSIONS Insulin resistance may not be characteristic of aging but rather associated with obesity and physical inactivity.
Keywords
Adult, Aged, Aging/physiology, Blood Glucose/metabolism, Body Mass Index, Diabetes Mellitus, Type 2/blood, Diabetes Mellitus, Type 2/epidemiology, Exercise/physiology, Glucose Clamp Technique, Humans, Insulin Resistance/physiology, Middle Aged, Obesity/blood, Obesity/complications, Physical Endurance, Sports/physiology
Pubmed
Web of science
Open Access
Yes
Create date
24/03/2011 9:35
Last modification date
20/08/2019 15:43
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