Effects of a sympathetic activation by a lower body negative pressure on glucose and lipid metabolism

Details

Serval ID
serval:BIB_C746C99C8242
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of a sympathetic activation by a lower body negative pressure on glucose and lipid metabolism
Journal
Clinical Physiology
Author(s)
Henry  S., Trueb  L., Sartori  C., Scherrer  U., Jequier  E., Tappy  L.
ISSN
0144-5979 (Print)
Publication state
Published
Issued date
11/1998
Volume
18
Number
6
Pages
562-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Abstract
The effects of a sympathetic activation elicited by a lower body negative pressure (LBNP) (at -15 mmHg for 75 min) were assessed in 7 healthy subjects on two occasions: (i) in post-absorptive conditions, and (ii) during glucose infusion (22.2 mumol kg-1 min-1). LBNP increased plasma norepinephrine concentration and heart rate. It did not alter whole-body glucose metabolism (measured with [6,6-2H]glucose) and glycerol turnover (measured with [1,1,2,3,3-2H]glycerol). Interstitial glycerol concentrations were monitored with microdialysis in subcutaneous adipose tissue and in skeletal muscle. LBNP increased dialysate glycerol concentrations in muscle by 16% (P < 0.03) but not in adipose tissue in post-absorptive conditions, and by 37% in adipose tissue (P < 0.05) but not in muscle during glucose infusion. These results indicate that an LBNP-induced sympathetic activation (i) does not increase endogenous glucose production, and (ii) induces only a slight stimulation of lipolysis in adipose tissue during glucose infusion.
Keywords
Adolescent Adult Blood Glucose/analysis Extracellular Space/metabolism Glucose/*metabolism/pharmacology Glycerol/metabolism/pharmacology Heart Rate/drug effects/physiology Humans Infusions, Intravenous Insulin/blood Leg/blood supply *Lipid Metabolism *Lower Body Negative Pressure Male Norepinephrine/blood Postprandial Period Regional Blood Flow/drug effects/physiology Sympathetic Nervous System/*physiology
Pubmed
Web of science
Create date
24/01/2008 14:36
Last modification date
20/08/2019 16:42
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