Simkania negevensis, an insight into the biology and clinical importance of a novel member of the Chlamydiales order.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_C74625116CCA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Simkania negevensis, an insight into the biology and clinical importance of a novel member of the Chlamydiales order.
Journal
Critical reviews in microbiology
Author(s)
Vouga M., Baud D., Greub G.
ISSN
1549-7828 (Electronic)
ISSN-L
1040-841X
Publication state
Published
Issued date
02/2017
Volume
43
Number
1
Pages
62-80
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish

Abstract
Simkania negevensis is a Chlamydia-related bacterium discovered in 1993 and represents the founding member of the Simkaniaceae family within the Chlamydiales order. As other Chlamydiales, it is an obligate intracellular bacterium characterized by a biphasic developmental cycle. Its similarities with the pathogenic Chlamydia trachomatis and Chlamydia pneumoniae make it an interesting bacterium. So far, little is known about its biology, but S. negevensis harbors various microbiological characteristics of interest, including a strong association of the Simkania-containing vacuole with the ER and the presence of an intron in the 23S rRNA encoding gene. Evidence of human exposition has been reported worldwide. However, there is a lack of robust clinical studies evaluating its implication in human diseases; current data suggest an association with pneumonia and bronchiolitis making S. negevensis a potential emerging pathogen. Owing to its fastidious growth requirements, the clinical relevance of S. negevensis is probably underestimated. In this review, we summarize the current knowledge on S. negevensis and explore future research challenges.

Keywords
Animals, Chlamydiales/classification, Chlamydiales/genetics, Chlamydiales/isolation & purification, Chlamydiales/physiology, Gram-Negative Bacterial Infections/microbiology, Humans, Phylogeny
Pubmed
Create date
20/01/2017 15:54
Last modification date
20/08/2019 16:42
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