Epidemiology of congenital cerebral anomalies in Europe: a multicentre, population-based EUROCAT study.

Details

Serval ID
serval:BIB_C732FA3212FA
Type
Article: article from journal or magazin.
Collection
Publications
Title
Epidemiology of congenital cerebral anomalies in Europe: a multicentre, population-based EUROCAT study.
Journal
Archives of disease in childhood
Author(s)
Morris J.K., Wellesley D.G., Barisic I., Addor M.C., Bergman JEH, Braz P., Cavero-Carbonell C., Draper E.S., Gatt M., Haeusler M., Klungsoyr K., Kurinczuk J.J., Lelong N., Luyt K., Lynch C., O'Mahony M.T., Mokoroa O., Nelen V., Neville A.J., Pierini A., Randrianaivo H., Rankin J., Rissmann A., Rouget F., Schaub B., Tucker D.F., Verellen-Dumoulin C., Wiesel A., Zymak-Zakutnia N., Lanzoni M., Garne E.
ISSN
1468-2044 (Electronic)
ISSN-L
0003-9888
Publication state
Published
Issued date
12/2019
Peer-reviewed
Oui
Volume
104
Number
12
Pages
1181-1187
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
To describe the epidemiology and geographical differences in prevalence of congenital cerebral anomalies in Europe.
Congenital cerebral anomalies (International Classification of Diseases, 10th Revision code Q04) recorded in 29 population-based EUROCAT registries conducting surveillance of 1.7 million births per annum (29% of all European births).
All birth outcomes (live births, fetal deaths from 20 weeks gestation and terminations of pregnancy after prenatal diagnosis of a fetal anomaly (TOPFA)) from 2005 to 2014.
Prevalence, proportion of associated non-cerebral anomalies, prenatal detection rate.
4927 cases with congenital cerebral anomalies were identified; a prevalence (adjusted for under-reporting) of 9.8 (95% CI: 8.5 to 11.2) per 10 000 births. There was a sixfold difference in prevalence across the registries. Registries with higher proportions of prenatal diagnoses had higher prevalence. Overall, 55% of all cases were liveborn, 3% were fetal deaths and 41% resulted in TOPFA. Forty-eight per cent of all cases were an isolated cerebral anomaly, 25% had associated non-cerebral anomalies and 27% were chromosomal or part of a syndrome (genetic or teratogenic). The prevalence excluding genetic or chromosomal conditions increased by 2.4% per annum (95% CI: 1.3% to 3.5%), with the increases occurring only for congenital malformations of the corpus callosum (3.0% per annum) and 'other reduction deformities of the brain' (2.8% per annum).
Only half of the cases were isolated cerebral anomalies. Improved prenatal and postnatal diagnosis may account for the increase in prevalence of congenital cerebral anomalies from 2005 to 2014. However, major differences in prevalence remain between regions.
Keywords
Child, Child, Preschool, Congenital Abnormalities/epidemiology, Europe/epidemiology, Female, Fetal Death, Humans, Infant, Infant, Newborn, International Classification of Diseases, Population Surveillance/methods, Pregnancy, Prevalence, Registries/statistics & numerical data, Stillbirth, congenital abnorm, epidemiology
Pubmed
Web of science
Create date
18/07/2019 18:33
Last modification date
27/04/2020 6:20
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