Cytokines, leptin, and the hypothalamo-pituitary-adrenal axis
Details
Serval ID
serval:BIB_C7226A6CCCC7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Cytokines, leptin, and the hypothalamo-pituitary-adrenal axis
Journal
Annals of the New York Academy of Sciences
ISSN
0077-8923 (Print)
Publication state
Published
Issued date
2000
Volume
917
Pages
647-57
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review
Research Support, Non-U.S. Gov't
Review
Abstract
The endocrine and immune systems are linked via an elaborated communication system constituted by an array of cytokines and neuropeptides which interact to modulate the integrated response of an organism to infection. Weight loss and anorexia, probably secondary to cytokine release, frequently accompany infection, but leptin could also play a role. Like cytokines, leptin serves as a peripheral messenger to convey signals to the brain. Expression of leptin is stimulated by glucocorticoids, endotoxins, and cytokines; on the other hand, leptin seems to inhibit the activation of the hypothalmo-pituitary-adrenal (HPA) axis. Indeed leptin exerts a direct, dose-dependent inhibition of stimulated cortisol secretion by normal human and rat adrenal cells in vitro. These effects are mediated by the long isoform of the leptin receptor, because its transcript is expressed in the adrenal tissue. In addition we investigated the role played by the glucocorticoids in the development of tolerance of the hypothalamo-corticotropic, immune and adipose system responses to repeated endotoxin administration. Unlike that of the corticotropic axis, tolerance of the immune and adipose systems is at least partially glucocorticoid-independent. This crosstalk between the endocrine, immune, and adipose systems may be of prime importance to homeostasis in pathophysiological events occurring during infection.
Keywords
Animals
Cytokines/*physiology
Humans
Hypothalamo-Hypophyseal System/*physiology
Leptin/*physiology
Neuroimmunomodulation
Pituitary-Adrenal System/*physiology
Pubmed
Web of science
Create date
25/01/2008 16:26
Last modification date
20/08/2019 15:42