A multi-omics approach to investigate the inflammatory response to life course socioeconomic position.

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_C6E5F1EF03CD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A multi-omics approach to investigate the inflammatory response to life course socioeconomic position.
Journal
Epigenomics
Author(s)
Castagné R., Kelly-Irving M., Krogh V., Palli D., Panico S., Sacerdote C., Tumino R., Hebels D.G., Kleinjans J.C., de Kok T.M., Georgiadis P., Kyrtopoulos S.A., Vermeulen R., Stringhini S., Vineis P., Chadeau-Hyam M., Delpierre C.
ISSN
1750-192X (Electronic)
ISSN-L
1750-192X
Publication state
Published
Issued date
08/2020
Peer-reviewed
Oui
Volume
12
Number
15
Pages
1287-1302
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials & methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results & conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.
Keywords
Adult, CpG Islands, DNA Methylation, Epigenome, Female, Humans, Inflammation/epidemiology, Italy/epidemiology, Male, Middle Aged, Social Class, Social Determinants of Health, DNA methylation, gene expression, inflammation, life course epidemiology, protein, socioeconomic position
Pubmed
Web of science
Open Access
Yes
Create date
15/09/2020 10:52
Last modification date
06/04/2024 7:35
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