A population-based evaluation of the seventh edition of the TNM system for lung cancer.

Details

Serval ID
serval:BIB_C6CF68E4E2CA
Type
Article: article from journal or magazin.
Collection
Publications
Title
A population-based evaluation of the seventh edition of the TNM system for lung cancer.
Journal
The European respiratory journal
Author(s)
Strand T.E., Rostad H., Wentzel-Larsen T., von Plessen C.
ISSN
1399-3003 (Electronic)
ISSN-L
0903-1936
Publication state
Published
Issued date
08/2010
Peer-reviewed
Oui
Volume
36
Number
2
Pages
401-407
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Our study describes the new seventh edition of the TNM system for lung cancer in a national population and its clinical implications. We classified 1,885 operated patients with lung cancer, reported to the Cancer Registry of Norway (Oslo, Norway) from 2001 to 2005, according to the sixth and the seventh edition of the TNM system. We compared survival differences adjusting for known prognostic factors. Furthermore, we evaluated the overall predictive ability of both editions using Harrell's concordance index. Survival curves by stage for each of the editions were similar; however, a better description of stage IIIB was observed in the seventh edition. Survival rates of T1b and T2a tumours were similar (log rank p = 0.94). The concordance index was 0.68 for both editions, indicating no overall difference in their predictive accuracy. In the seventh edition, 211 (29%) stage IB patients migrated to stage II and 161 (48%) patients migrated from stage IIB to IIA. Stage migrations could change the treatment for up to 326 (17.3%) of the study patients. The seventh edition did not improve the overall predictive ability of the TNM system; however, the new classification implies changes in treatment for nearly one-fifth of the cases. The implications of the seventh TNM edition for the outcomes of patients should be studied further.
Keywords
Adult, Aged, Aged, 80 and over, Female, Humans, Lung Neoplasms/diagnosis, Lung Neoplasms/mortality, Lung Neoplasms/pathology, Male, Middle Aged, Neoplasm Metastasis, Neoplasm Staging, Prospective Studies, Pulmonary Medicine/methods, Pulmonary Medicine/standards, Registries, Reproducibility of Results, Survival Rate
Pubmed
Web of science
Open Access
Yes
Create date
10/03/2023 12:43
Last modification date
28/04/2023 5:54
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