Hypothyroid myopathy as a complication of interferon alpha therapy for chronic hepatitis C virus infection.

Details

Serval ID
serval:BIB_C6B98B30C7B3
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Hypothyroid myopathy as a complication of interferon alpha therapy for chronic hepatitis C virus infection.
Journal
British journal of rheumatology
Author(s)
Ghilardi G., Gonvers J.J., So A.
ISSN
0263-7103
Publication state
Published
Issued date
1998
Peer-reviewed
Oui
Volume
37
Number
12
Pages
1349-51
Language
english
Notes
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
Abstract
Interferon alpha (IFN-alpha) therapy is associated with a number of immunological side-effects, including autoimmune diseases and a 10% prevalence of thyroiditis. Hepatitis C virus (HCV) infection itself predisposes to autoimmune phenomena including hypothyroidism and myositis. The development of clinical hypothyroidism in the presence of positive thyroid antibodies in patients infected with HCV and treated with IFN-alpha suggests a possible association between the viral disease and the therapy. HCV infection may predispose to autoimmune thyroid disease and IFN-alpha therapy may secondarily lead to the development of thyroid dysfunctions. We report the single case of a female patient who developed a severe proximal myopathy in conjunction with primary hypothyroidism (Hoffmann's syndrome) secondarily to IFN-alpha therapy for HCV infection. This case highlights the need for careful clinical and biological monitoring for potential side-effects in such patients.
Keywords
Adult, Female, Hepatitis C, Chronic, Humans, Hypothyroidism, Interferon-alpha, Myositis, Thyroiditis, Autoimmune
Pubmed
Web of science
Create date
25/01/2008 9:38
Last modification date
20/08/2019 16:42
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