Modeling the Influence of Age on Neurological Outcome and Quality of Life One Year after Traumatic Brain Injury: A Prospective Multi-Center Cohort Study.

Details

Serval ID
serval:BIB_C6AAAD7C879D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Modeling the Influence of Age on Neurological Outcome and Quality of Life One Year after Traumatic Brain Injury: A Prospective Multi-Center Cohort Study.
Journal
Journal of neurotrauma
Author(s)
Bouzat P., Ageron F.X., Thomas M., Vallot C., Hautefeuille S., Schilte C., Payen J.F.
ISSN
1557-9042 (Electronic)
ISSN-L
0897-7151
Publication state
Published
Issued date
01/09/2019
Peer-reviewed
Oui
Volume
36
Number
17
Pages
2506-2512
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
After traumatic brain injury (TBI), the relationship between age and outcome at 1 year, including quality of life, has been poorly explored. The aim of our study was to describe this relationship in a cohort of TBI patients in a regional trauma system. Consecutive TBI patients with severe lesions on initial brain computed tomography (CT) scan were included from July 2014 to July 2016 in two French level-1 trauma centers. The primary outcome was the mortality at 1 year and secondary outcomes were Glasgow Outcome Scale-Extended (GOS-E) and quality of life using the Short Form Health Survey (SF-12). The relationship between age and outcome was modeled using the generalized linear model (GLM). Within the study period, 427 patients with TBI and type 3 Abbreviated Injury Scale (AIS) lesions were included. Finally, 380 patients were assessed for mortality. Ninety-six (25%) patients died at 1 year. The detailed neurological status was available for 317 patients. One year after the trauma, 141 (44%) patients had a favorable outcome (GOS-E 7 and 8), whereas 53 (17%) patients had a moderate disability (GOS-E 5-6), 27 (9%) patients had a severe disability or were in a vegetative state (GOS-E 2-4), and 96 (30%) patients had died (GOS-E 1). After 70 years of age, a dramatic increase in the odds of death and poor neurological outcome was found using GLM. No difference according to age was found for the quality of life. After TBI, the mortality at 1 year dramatically increased with age after 70 years. For elderly survivors, impairment of quality of life was not different from younger patients.
Keywords
outcome, quality of life, severe trauma, traumatic brain injury
Pubmed
Web of science
Create date
20/02/2020 10:38
Last modification date
15/07/2020 5:26
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