Treatment of cachexia with recombinant growth hormone in a patient before lung transplantation: a case report.

Details

Serval ID
serval:BIB_C6A4D56AE04E
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Treatment of cachexia with recombinant growth hormone in a patient before lung transplantation: a case report.
Journal
Critical Care Medicine
Author(s)
Pichard C., Kyle U.G., Jolliet P., Slosman D.O., Rochat T., Nicod L., Romand J., Mensi N., Chevrolet J.C.
ISSN
0090-3493 (Print)
ISSN-L
0090-3493
Publication state
Published
Issued date
1999
Volume
27
Number
8
Pages
1639-1642
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
OBJECTIVES: To describe the effects of recombinant human growth hormone (rhGH) in a severely malnourished patient before lung transplantation.
DESIGN: Case study.
SETTING: Intensive care unit.
PATIENTS: A 38-yr-old severely malnourished (body mass index, 15.1 kg/m2) woman (receiving prednisone) with bronchiolitis obliterans evolving during 10 yrs presented with end-stage lung disease and required continuous noninvasive mechanical ventilation.
INTERVENTIONS: Two courses of 35 days of 16 IU/day (0.42 IU/kg/day) rhGH administered subcutaneously, with an interruption of 5 wks between the two courses of rhGH.
MEASUREMENTS AND MAIN RESULTS: Weight gain of 14.7% and 12.8% fat-free mass, as measured by 50-kHz bioelectrical impedance analysis, during treatment during a 3.5-month period. Nitrogen excretion decreased from 23.7 g/day before treatment to 8.0 g/day while receiving rhGH. Improvement of pulmonary function was also noted and allowed discharge of the patient from the hospital after the second course of rhGH. She underwent successful lung transplantation 2 months later and reached 48.8 kg of body weight 6 months later.
CONCLUSIONS: rhGH treatment is a possible strategy that could be used with malnourished patients who are awaiting lung transplantation to improve the nutritional status and respiratory muscle function to prevent recurring respiratory infection and postoperative complications favored by malnutrition and possibly to decrease the length of hospital stay.
Keywords
Adult, Anti-Inflammatory Agents/therapeutic use, Body Composition, Body Mass Index, Bronchiolitis Obliterans/complications, Bronchiolitis Obliterans/surgery, Cachexia/drug therapy, Female, Human Growth Hormone/therapeutic use, Humans, Length of Stay, Lung Transplantation, Nitrogen/metabolism, Nutrition Assessment, Nutritional Status, Plethysmography, Impedance, Prednisone/therapeutic use, Preoperative Care/methods, Protein-Energy Malnutrition/complications, Protein-Energy Malnutrition/diagnosis
Pubmed
Web of science
Create date
19/02/2010 18:52
Last modification date
20/08/2019 15:42
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