Psychosocial deficits across autism and schizotypal spectra are interactively modulated by excitatory and inhibitory neurotransmission.

Details

Serval ID
serval:BIB_C67AE2781587
Type
Article: article from journal or magazin.
Collection
Publications
Title
Psychosocial deficits across autism and schizotypal spectra are interactively modulated by excitatory and inhibitory neurotransmission.
Journal
Autism
Author(s)
Ford T.C., Crewther D.P., Abu-Akel A.
ISSN
1461-7005 (Electronic)
ISSN-L
1362-3613
Publication state
Published
Issued date
02/2020
Peer-reviewed
Oui
Volume
24
Number
2
Pages
364-373
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Continued human and animal research has strengthened evidence for aberrant excitatory-inhibitory neural processes underlying autism and schizophrenia spectrum disorder psychopathology, particularly psychosocial functioning, in clinical and nonclinical populations. We investigated the extent to which autistic traits and schizotypal dimensions were modulated by the interactive relationship between excitatory glutamate and inhibitory GABA neurotransmitter concentrations in the social processing area of the superior temporal cortex using proton magnetic resonance spectroscopy. In total, 38 non-clinical participants (20 females; age range = 18-35 years, mean (standard deviation) = 23.22 (5.52)) completed the autism spectrum quotient and schizotypal personality questionnaire, and underwent proton magnetic resonance spectroscopy to quantify glutamate and GABA concentrations in the right and left superior temporal cortex. Regression analyses revealed that glutamate and GABA interactively modulated autistic social skills and schizotypal interpersonal features (p <sub>corr</sub> < 0.05), such that those with high right superior temporal cortex glutamate but low GABA concentrations exhibited poorer social and interpersonal skills. These findings evidence an excitation-inhibition imbalance that is specific to psychosocial features across the autism and schizophrenia spectra.
Keywords
Developmental and Educational Psychology, GABA, autism, glutamate, magnetic resonance spectroscopy, schizophrenia, social behavior, social cognition
Pubmed
Web of science
Create date
25/07/2019 10:17
Last modification date
26/01/2020 7:19
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