Nutritional papers in ICU patients: what lies between the lines?

Details

Serval ID
serval:BIB_C67038727C6B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Nutritional papers in ICU patients: what lies between the lines?
Journal
Intensive Care Medicine
Author(s)
Preiser  J. C., Chiolero  R., Wernerman  J.
ISSN
0342-4642 (Print)
Publication state
Published
Issued date
02/2003
Volume
29
Number
2
Pages
156-166
Notes
Journal Article Review --- Old month value: Feb
Abstract
The abundance of literature related to nutritional support reflects its recently recognised role in preventing metabolic complications and gut dysfunction during critical illness. However, some published studies lack relevance to critically ill patients, as a result of the selection of subjects and outcome variables, or flaws in the study design, as well as in the type, composition, timing, route of administration and amount of nutritional support given. This review will highlight these confounding factors by describing two imaginary (but typical) clinical trials and by analysing some studies published. The point at issue is that basic quality requirements, such as the formulation of a prospective hypothesis and the delineation of the effects of the reference treatment, are often lacking in many studies published. Data analysis was often found to be biased by the absence of statistical power calculation and intention-to-treat analysis. Globally, studies designed to assess the effects of nutritional support on the outcome of critically ill patients, rarely fulfil basic quality requirements and should therefore be interpreted cautiously. We suggest simple strategies or study design that will allow important questions to be answered by future clinical trials.
Keywords
Clinical Trials/*standards Cost-Benefit Analysis Critical Illness/mortality/*therapy Data Interpretation, Statistical Energy Metabolism Guidelines Hospital Mortality Humans Information Storage and Retrieval Intensive Care/economics/*methods/standards Length of Stay Medline Nutritional Requirements Nutritional Support/economics/*methods/standards Publishing Research Design/*standards Safety Selection Bias Time Factors Treatment Outcome
Pubmed
Web of science
Create date
24/01/2008 16:52
Last modification date
20/08/2019 15:41
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