An overview of corneal collagen cross-linking (CXL).

Details

Serval ID
serval:BIB_C646E5BAB65C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
An overview of corneal collagen cross-linking (CXL).
Journal
Advances in therapy
Author(s)
Kymionis G.D., Mikropoulos D.G., Portaliou D.M., Voudouragkaki I.C., Kozobolis V.P., Konstas A.G.
ISSN
1865-8652 (Electronic)
ISSN-L
0741-238X
Publication state
Published
Issued date
10/2013
Peer-reviewed
Oui
Volume
30
Number
10
Pages
858-869
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Corneal collagen cross-linking (CXL) was first described over a decade ago and is now considered to be one of the most important surgical innovations of modern ophthalmology. Prior to its introduction, no interventions were available to arrest, or slow down ectatic disease progression, with corneal transplantation required in the majority of cases. Unlike earlier treatments of corneal ectasias that attempted to only improve the consequences of the disease, CXL aims to address the corneal biomechanical weakening itself. The long-term safety and efficacy of CXL have been established in several studies that have documented significant improvements in all outcome measures (visual acuity, spherical equivalent, astigmatism, and keratometric findings). The emerging combination of CXL with other interventions (termed 'CXL plus') optimizes the visual and topographic outcomes. This, along with the expansion of the techniques' indications for other clinical conditions, such as microbial keratitis, highlights the continuous improvement of the initial technique and confirms its wide acceptance. Overall, CXL has already demonstrated much promise and has several clinical indications, representing a clear example of recent advances in ocular therapy.
Keywords
Collagen/metabolism, Corneal Diseases/radiotherapy, Corneal Ulcer/radiotherapy, Eye Infections, Bacterial/radiotherapy, Humans, Keratitis/radiotherapy, Keratoconus/radiotherapy, Photosensitizing Agents/therapeutic use, Riboflavin/therapeutic use, Ultraviolet Therapy/methods
Pubmed
Web of science
Create date
01/10/2019 12:55
Last modification date
06/10/2019 5:26
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