Drosophila germ-line modulation of insulin signaling and lifespan.

Details

Serval ID
serval:BIB_C635709629BD
Type
Article: article from journal or magazin.
Collection
Publications
Title
Drosophila germ-line modulation of insulin signaling and lifespan.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Flatt T., Min K.J., D'Alterio C., Villa-Cuesta E., Cumbers J., Lehmann R., Jones D.L., Tatar M.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
105
Number
17
Pages
6368-6373
Language
english
Abstract
Ablation of germ-line precursor cells in Caenorhabditis elegans extends lifespan by activating DAF-16, a forkhead transcription factor (FOXO) repressed by insulin/insulin-like growth factor (IGF) signaling (IIS). Signals from the gonad might thus regulate whole-organism aging by modulating IIS. To date, the details of this systemic regulation of aging by the reproductive system are not understood, and it is unknown whether such effects are evolutionarily conserved. Here we report that eliminating germ cells (GCs) in Drosophila melanogaster increases lifespan and modulates insulin signaling. Long-lived germ-line-less flies show increased production of Drosophila insulin-like peptides (dilps) and hypoglycemia but simultaneously exhibit several characteristics of IIS impedance, as indicated by up-regulation of the Drosophila FOXO (dFOXO) target genes 4E-BP and l (2)efl and the insulin/IGF-binding protein IMP-L2. These results suggest that signals from the gonad regulate lifespan and modulate insulin sensitivity in the fly and that the gonadal regulation of aging is evolutionarily conserved.
Keywords
Animals, Drosophila Proteins/genetics, Drosophila Proteins/metabolism, Drosophila melanogaster/genetics, Drosophila melanogaster/metabolism, Female, Gene Expression Regulation, Genes, Insect, Germ Cells/cytology, Germ Cells/metabolism, Insulin/metabolism, Longevity, Male, Ovary/cytology, RNA, Messenger/genetics, RNA, Messenger/metabolism, Signal Transduction, Testis/cytology
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2013 12:27
Last modification date
20/08/2019 15:41
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