FXYD proteins: new tissue-specific regulators of the ubiquitous Na,K-ATPase

Details

Serval ID
serval:BIB_C62C92AC0707
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
FXYD proteins: new tissue-specific regulators of the ubiquitous Na,K-ATPase
Journal
Science's STKE
Author(s)
Crambert  G., Geering  K.
ISSN
1525-8882 (Electronic)
Publication state
Published
Issued date
01/2003
Volume
2003
Number
166
Pages
RE1
Notes
Journal Article
Review --- Old month value: Jan 21
Abstract
Maintenance of the Na+ and K+ gradients between the intracellular and extracellular milieus of animal cells is a prerequisite for basic cellular homeostasis and for functions of specialized tissues. The Na,K-ATPase, an oligomeric P-type adenosine triphosphatase (ATPase), is composed of a catalytic alpha subunit and a regulatory beta subunit and is the main player that fulfils these tasks. A variety of regulatory mechanisms are necessary to guarantee appropriate Na,K-ATPase expression and activity adapted to changing physiological demands. Recently, a regulatory mechanism was defined that is mediated by interaction of Na,K-ATPase with small proteins of the FXYD family, which possess a single transmembrane domain and so far have been considered as channels or regulators of ion channels. The mammalian FXYD proteins FXYD1 through FXYD7 exhibit tissue-specific distribution. Phospholemman (FXYD1) in heart and skeletal muscle, the gamma subunit of Na,K-ATPase (FXYD2) and corticosteroid hormone-induced factor (FXYD4, also known as CHIF) in the kidney, and FXYD7 in the brain associate preferentially with the widely expressed Na,K-ATPase alpha1-beta1 isozyme and modulate its transport activity in a way that conforms to tissue-specific requirements. Thus, tissue- and isozyme-specific interaction of Na,K-ATPase with FXYD proteins contributes to proper handling of Na+ and K+ by the Na,K-ATPase, and ensures correct function in such processes as renal Na+-reabsorption, muscle contraction, and neuronal excitability.
Keywords
Animals Humans Membrane Glycoproteins/biosynthesis/*physiology Membrane Proteins/biosynthesis/*physiology Na(+)-K(+)-Exchanging ATPase/biosynthesis/*metabolism/*physiology Neoplasm Proteins/biosynthesis/*physiology Nerve Tissue Proteins/biosynthesis/*physiology Organ Specificity/physiology
Pubmed
Create date
24/01/2008 12:28
Last modification date
20/08/2019 15:41
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