Intracerebral recordings of nocturnal hyperkinetic seizures: demonstration of a longer duration of the pre-seizure sleep spindle

Details

Serval ID
serval:BIB_C5F1F7D2CF55
Type
Article: article from journal or magazin.
Collection
Publications
Title
Intracerebral recordings of nocturnal hyperkinetic seizures: demonstration of a longer duration of the pre-seizure sleep spindle
Journal
Clin Neurophysiol
Author(s)
Picard F., Megevand P., Minotti L., Kahane P., Ryvlin P., Seeck M., Michel C. M., Lantz G.
ISSN
1388-2457 (Print)
ISSN-L
1388-2457
Publication state
Published
Issued date
04/2007
Volume
118
Number
4
Pages
928-39
Language
english
Notes
Picard, F
Megevand, P
Minotti, L
Kahane, P
Ryvlin, P
Seeck, M
Michel, C M
Lantz, G
eng
Case Reports
Research Support, Non-U.S. Gov't
Netherlands
Clin Neurophysiol. 2007 Apr;118(4):928-39. doi: 10.1016/j.clinph.2006.12.014. Epub 2007 Feb 20.
Abstract
OBJECTIVE: Nocturnal frontal lobe epilepsy (NFLE) seizures occur primarily during non-rapid eye movement sleep stage 2. We observed in several patients rhythms of same localization and frequency as sleep spindles, immediately preceding and sometimes continuing at seizure onsets. We aimed to study the link between sleep spindles and seizure onsets. METHODS: We used intracerebral stereo-EEG ictal recordings of two MRI-negative patients with clinically defined NFLE. For each of the six studied seizures, sustained activity in the frontal sleep spindle frequency (12Hz) was observed around seizure onset. The duration of this pre-seizure sleep spindle was compared to that of the 10 preceding sleep spindles. RESULTS: The pre-seizure sleep spindles were clearly of longer duration than the "interictal" sleep spindles for all seizures. This sustained pre-seizure 12Hz activity could be differentiated from normal awakenings, and showed no spatial relation to the ictal onset. CONCLUSIONS: We demonstrated a functional alteration of the sleep spindle-generating thalamocortical loop concomitant with the seizure onsets. This defect may also be involved in seizure generation. SIGNIFICANCE: A thalamic participation in NFLE pathogenesis is likely in our two patients. The study of additional patients will allow to evaluate the role of the thalamocortical circuits in NFLE.
Keywords
Adolescent, Brain Mapping, Child, *Electroencephalography, Female, Humans, Male, Polysomnography/methods, Seizures/*physiopathology, *Sleep
Pubmed
Create date
29/11/2018 12:37
Last modification date
20/08/2019 15:41
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