Naturally acquired cellular immune responses to the synthetic malarial peptide SPf66 in children in Papua New Guinea

Details

Serval ID
serval:BIB_C5EF02D968E3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Naturally acquired cellular immune responses to the synthetic malarial peptide SPf66 in children in Papua New Guinea
Journal
Transactions of the Royal Society of Tropical Medicine and Hygiène
Author(s)
al-Yaman  F., Genton  B., Taraika  J., Alpers  M. P.
ISSN
0035-9203 (Print)
Publication state
Published
Issued date
12/1997
Volume
91
Number
6
Pages
709-12
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Nov-Dec
Abstract
A prospective longitudinal study to examine the relationship between cellular immune responses to the synthetic malarial peptide SPf66 and malaria infection and morbidity was carried out in 187 children aged 0.5-15 years in the Wosera area of Papua New Guinea. Cellular responses were assessed by proliferation and stimulation of cytokines representing the Th1 and Th2 cell subsets (interferon gamma [IFN gamma] and interleukin-4 [IL-4]. Most children (66%) did not respond to SPf66 by any measure. Among the responders, the highest response was obtained for IL-4 (19%) followed by IFN gamma (10%), and the least for proliferation (5%). Analyses of the relation of T cell response to malaria infection showed that the IFN gamma response to SPf66 was positively correlated with parasite density (r = 0.27, P = 0.001). There was no association between the cellular response to SPf66 and concurrent or subsequent malaria morbidity, whichever clinical definition was used. Thus none of these cellular immune responses predicted efficacy of SPf66 in this highly endemic area.
Keywords
Adolescent Child Child, Preschool Cohort Studies *Endemic Diseases Fever/immunology Humans Immunity, Cellular/immunology Infant Interferon Type II/blood Interleukin-4/blood Longitudinal Studies Malaria Vaccines/*immunology Malaria, Falciparum/*immunology Papua New Guinea Parasitemia/immunology Prospective Studies Vaccines, Synthetic/*immunology
Pubmed
Web of science
Create date
28/01/2008 11:49
Last modification date
20/08/2019 15:41
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