Lack of correlation between structural properties and biological activity of two cross-reacting cytochrome c T cell epitopes as determined by circular dichroism measurements

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Serval ID
serval:BIB_C5EC4FF4E880
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lack of correlation between structural properties and biological activity of two cross-reacting cytochrome c T cell epitopes as determined by circular dichroism measurements
Journal
Molecular Immunology
Author(s)
Vita  C., Baumhuter  S., Corradin  G.
ISSN
0161-5890 (Print)
Publication state
Published
Issued date
03/1990
Volume
27
Number
3
Pages
291-5
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Abstract
Horse and tuna cytochrome c synthetic peptides 39-53 can equally well stimulate a cytochrome c specific T cell hybridoma. The amino acid sequence of the two peptides differs mainly for the presence of a helix-breaking proline and a helix-forming glutamic acid in position 44. Circular dichroism studies of these two peptides revealed that their conformation could be drastically depending on the solvent used. These data place some limits on the correlation between structural data and biological activity.
Keywords
Animals Circular Dichroism Cross Reactions/immunology Cytochrome c Group/*immunology Epitopes/*immunology Horses Structure-Activity Relationship T-Lymphocytes/*immunology Tuna
Pubmed
Web of science
Create date
24/01/2008 14:55
Last modification date
20/08/2019 15:41
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