Attachment, Neurobiology, and Mentalizing along the Psychosis Continuum.

Details

Serval ID
serval:BIB_C5E9F993AC97
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Attachment, Neurobiology, and Mentalizing along the Psychosis Continuum.
Journal
Frontiers in human neuroscience
Author(s)
Debbané M., Salaminios G., Luyten P., Badoud D., Armando M., Solida Tozzi A., Fonagy P., Brent B.K.
ISSN
1662-5161 (Print)
ISSN-L
1662-5161
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
10
Pages
406
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
In this review article, we outline the evidence linking attachment adversity to psychosis, from the premorbid stages of the disorder to its clinical forms. To better understand the neurobiological mechanisms through which insecure attachment may contribute to psychosis, we identify at least five neurobiological pathways linking attachment to risk for developing psychosis. Besides its well documented influence on the hypothalamic-pituary-adrenal (HPA) axis, insecure attachment may also contribute to neurodevelopmental risk through the dopaminergic and oxytonergic systems, as well as bear influence on neuroinflammation and oxidative stress responses. We further consider the neuroscientific and behavioral studies that underpin mentalization as a suite of processes potentially moderating the risk to transition to psychotic disorders. In particular, mentalization may help the individual compensate for endophenotypical impairments in the integration of sensory and metacognitive information. We propose a model where embodied mentalization would lie at the core of a protective, resilience response mitigating the adverse and potentially pathological influence of the neurodevelopmental cascade of risk for psychosis.
Keywords
HPA, UHR, mentalizing, schizophrenia, schizotypy, self, theory of mind
Pubmed
Web of science
Open Access
Yes
Create date
09/10/2020 21:18
Last modification date
10/10/2020 5:26
Usage data