Drug vaping applied to cannabis: Is "Cannavaping" a therapeutic alternative to marijuana?

Details

Ressource 1Download: BIB_C5A7CB0765F3.P001.pdf (873.81 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_C5A7CB0765F3
Type
Article: article from journal or magazin.
Collection
Publications
Title
Drug vaping applied to cannabis: Is "Cannavaping" a therapeutic alternative to marijuana?
Journal
Scientific Reports
Author(s)
Varlet V., Concha-Lozano Nicolas, Berthet Aurélie, Plateel Gregory, Favrat B., De Cesare M., Lauer E., Augsburger M., Thomas A., Giroud C.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
26/05/2016
Peer-reviewed
Oui
Volume
6
Pages
25599
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Therapeutic cannabis administration is increasingly used in Western countries due to its positive role in several pathologies. Dronabinol or tetrahydrocannabinol (THC) pills, ethanolic cannabis tinctures, oromucosal sprays or table vaporizing devices are available but other cannabinoids forms can be used. Inspired by the illegal practice of dabbing of butane hashish oil (BHO), cannabinoids from cannabis were extracted with butane gas, and the resulting concentrate (BHO) was atomized with specific vaporizing devices. The efficiency of "cannavaping," defined as the "vaping" of liquid refills for e-cigarettes enriched with cannabinoids, including BHO, was studied as an alternative route of administration for therapeutic cannabinoids. The results showed that illegal cannavaping would be subjected to marginal development due to the poor solubility of BHO in commercial liquid refills (especially those with high glycerin content). This prevents the manufacture of liquid refills with high BHO concentrations adopted by most recreational users of cannabis to feel the psychoactive effects more rapidly and extensively. Conversely, "therapeutic cannavaping" could be an efficient route for cannabinoids administration because less concentrated cannabinoids-enriched liquid refills are required. However, the electronic device marketed for therapeutic cannavaping should be carefully designed to minimize potential overheating and contaminant generation.
Keywords
Butanes/administration & dosage, Butanes/therapeutic use, Cannabinoids/administration & dosage, Cannabinoids/therapeutic use, Cannabis/chemistry, Dronabinol/administration & dosage, Dronabinol/therapeutic use, Electronic Nicotine Delivery Systems/instrumentation, Electronic Nicotine Delivery Systems/methods, Feasibility Studies, Humans, Marijuana Smoking, Medical Marijuana/administration & dosage, Medical Marijuana/therapeutic use, Reproducibility of Results, Vaping/instrumentation, Vaping/methods
Pubmed
Web of science
Open Access
Yes
Create date
31/05/2016 9:30
Last modification date
20/08/2019 15:41
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