Molekulare Aspekte des hepatozellularen Karzinoms. [Molecular aspects of hepatocellular carcinoma]
Details
Serval ID
serval:BIB_C5959E857BA9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Molekulare Aspekte des hepatozellularen Karzinoms. [Molecular aspects of hepatocellular carcinoma]
Journal
Zentralblatt fur Chirurgie
ISSN
0044-409X (Print)
Publication state
Published
Issued date
2000
Volume
125
Number
7
Pages
592-6
Notes
English Abstract
Journal Article
Journal Article
Abstract
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. The major risk factors for HCC development are now well defined and some of the multiple steps involved in hepatocarcinogenesis have been elucidated in recent years. However, no clear picture of how and in what sequence these factors interact at the molecular level has emerged yet. Malignant transformation of hepatocytes may occur as a consequence of various etiologies, such as chronic viral hepatitis, alcohol, and metabolic disorders, in the context of increased cellular turnover induced by chronic liver injury, regeneration and cirrhosis. Activation of cellular oncogenes, inactivation of tumor suppressor genes, overexpression of certain growth factors, and possibly telomerase activation and DNA mismatch repair defects may contribute to the development of HCC. Finally, aflatoxins have been shown to induce specific mutations of the p53 tumor suppressor gene, thus pointing to the contribution of environmental factors to tumor development at the molecular level.
Keywords
Adult
Aflatoxin B1/toxicity
Age Factors
Alcoholism/complications
Animals
Carcinoma, Hepatocellular/epidemiology/etiology/*genetics
Child
Cohort Studies
DNA/genetics
DNA Repair
Enzyme Activation
Genes, p53/genetics
Growth Substances/genetics
Hepatitis B, Chronic/complications
Humans
Liver Cirrhosis/complications
Liver Neoplasms/epidemiology/etiology/*genetics
Marmota
Mice
Mice, Transgenic
Middle Aged
Mutation
Risk Factors
Telomerase/metabolism
Pubmed
Web of science
Create date
25/01/2008 17:06
Last modification date
20/08/2019 16:41