Effect of pre-term birth on oxidative stress responses to normoxic and hypoxic exercise.

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State: Public
Version: author
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_C519E7F25D0E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of pre-term birth on oxidative stress responses to normoxic and hypoxic exercise.
Journal
Redox biology
Author(s)
Martin A., Millet G., Osredkar D., Mramor M., Faes C., Gouraud E., Debevec T., Pialoux V.
ISSN
2213-2317 (Electronic)
ISSN-L
2213-2317
Publication state
Published
Issued date
05/03/2020
Peer-reviewed
Oui
Volume
32
Pages
101497
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Pre-term birth is a major health concern that occurs in approximately 10% of births worldwide. Despite high incidence rate, long-term consequences of pre-term birth remain unclear. Recent evidence suggests that elevated oxidative stress observed in pre-term born infants could persist into adulthood. Given that oxidative stress is known to play an important role in response to physical activity and hypoxia, we investigated whether oxidative stress responses to acute exercise in normoxia and hypoxia may be differently modulated in pre-term vs. full-term born adults. Twenty-two pre-term born and fifteen age-matched full-term born controls performed maximal incremental cycling tests in both normoxia (FiO2: 0.21) and normobaric hypoxia (FiO2: 0.13; simulated altitude of 3800 m) in blinded and randomized manner. Plasma levels of oxidative stress (advanced oxidation protein products [AOPP] and malondialdehyde), antioxidant (ferric reducing antioxidant power, glutathione peroxidase, catalase [CAT] and superoxide dismutase [SOD]) and nitrosative stress markers (nitrotyrosine, nitrite and total nitrite and nitrate [NOx]) were measured before and immediately after each test. AOPP (+24%, P<0.001), CAT (+38%, P<0.001) and SOD (+12%, P=0.018) and NOx (+17%, P=0.024) significantly increased in response to exercise independently of condition and birth status. No difference in response to acute exercise in normoxia was noted between pre-term and full-term born adults in any of measured markers. Hypoxic exposure during exercise resulted in significant increase in AOPP (+45%, P=0.008), CAT (+55%, P=0.019) and a trend for an increase in nitrite/nitrate content (+35%, P=0.107) only in full-term and not pre-term born individuals. These results suggest that prematurely born adult individuals exhibit higher resistance to oxidative stress response to exercise in hypoxia.
Keywords
Altitude, Exercise, Nitrosative stress, Normobaric hypoxia, Oxidative stress, Prematurity
Pubmed
Open Access
Yes
Create date
01/04/2020 20:22
Last modification date
22/02/2021 10:43
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