Mechanisms of successful amoxicillin prophylaxis of experimental endocarditis due to Streptococcus intermedius.

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Serval ID
serval:BIB_C4D644F94BB5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Mechanisms of successful amoxicillin prophylaxis of experimental endocarditis due to Streptococcus intermedius.
Journal
Journal of Infectious Diseases
Author(s)
Moreillon P., Francioli P., Overholser D., Meylan P., Glauser M.P.
ISSN
0022-1899 (Print)
ISSN-L
0022-1899
Publication state
Published
Issued date
1986
Volume
154
Number
5
Pages
801-807
Language
english
Abstract
Prophylaxis with amoxicillin (40 mg/kg) was studied in rats with aortic valve vegetations. Bacteria on the valves were quantitated early (10 min to 6 hr) and late (three days) after intravenous challenge with tolerant Streptococcus intermedius. Amoxicillin reduced by 40% the number of bacteria per valve 10 min after intravenous challenge with 10(5) S. intermedius (P less than .05) and by 74% the incidence of endocarditis three days thereafter (P less than .0001). Bacterial multiplication started 2 hr after challenge in control rats, whereas bacteria disappeared in 6 hr in amoxicillin-treated rats. Intravenous penicillinase 30 min after challenge abolished successful amoxicillin prophylaxis, a result demonstrating the necessity of prolonged growth inhibition for protection. Growth inhibition for 18 hr (two subsequent amoxicillin doses) was necessary for protection after intravenous challenge with 10(5) S. intermedius. Thus, in the absence of bacterial killing, inhibition of valvular colonization by amoxicillin was not as important a mechanism of endocarditis prophylaxis as was prolonged inhibition of bacterial growth, which allowed adherent bacteria to be cleared from the valves.
Keywords
Amoxicillin/therapeutic use, Animals, Endocarditis/drug therapy, Penicillinase/metabolism, Rats, Streptococcal Infections/drug therapy, Time Factors
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 13:57
Last modification date
01/10/2019 6:19
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