Relationship between the airway wall area and asthma control score in moderate persistent asthma.

Details

Serval ID
serval:BIB_C4A6E9631ECB
Type
Article: article from journal or magazin.
Collection
Publications
Title
Relationship between the airway wall area and asthma control score in moderate persistent asthma.
Journal
European Radiology
Author(s)
Brillet P.Y., Grenier P.A., Fetita C.I., Beigelman-Aubry C., Ould-Hmeidi Y., Ortner M., Nachbaur G., Adamek L., Chanez P.
ISSN
1432-1084 (Electronic)
ISSN-L
0938-7994
Publication state
Published
Issued date
06/2013
Peer-reviewed
Oui
Volume
23
Number
6
Pages
1594-1602
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
OBJECTIVES: To assess the association between airway wall area and clinical asthma control, assessed by the Asthma Control Test (ACT).
METHODS: This cross-sectional study evaluated 96 adults for asthma control ["at least well controlled" (ACT â0/00¥ 20; n = 52) or "not well controlled" (ACT < 20; n = 44) and airway dimensions: luminal area (LA), wall area (WA) and WA%], obtained using automated dedicated software measurements from volumetric CT images. Results were analysed for segmental bronchi, subsegmental bronchi in the right upper lobe and basilar segments, both uncorrected and corrected for body surface area (BSA).
RESULTS: For all bronchi corrected for BSA, there was no correlation between airway wall area and ACT score. There was a weak but statistically significant correlation between uncorrected WA and ACT score (r = -0.203; P = 0.047); WA values were numerically higher in the "not well-controlled" versus the "at least well-controlled asthma" subgroups. For sub-segmental bronchi, there was a correlation between the ACT score and both WA/BSA (r = -0.204; P = 0.047) and WA (r = -0.249; P = 0.014), and for upper lobe bronchi, between the ACT score and WA (r = -0.207; P = 0.044).
CONCLUSION: We demonstrated a correlation between subsegmental bronchial airway measurements and clinical control of asthma; this is probably a reflection of airway remodelling and structural changes in chronic poorly controlled asthma. KEY POINTS : âeuro¢ Volumetric computed tomography offers new insights into bronchial morphology. âeuro¢ The relationship between current asthma control and airway wall abnormalities is assessed. âeuro¢ Some relationships between airway wall area and clinical control were demonstrated. âeuro¢ We observed less shape variation of bronchi in "not well-controlled" asthma patients.
Pubmed
Web of science
Create date
15/08/2013 15:02
Last modification date
20/08/2019 15:40
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