[Progressive renal failure caused by lithium nephropathy]
Details
Serval ID
serval:BIB_C49A4B0A5DCD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
[Progressive renal failure caused by lithium nephropathy]
Journal
Presse Med
ISSN
0755-4982 (Print)
ISSN-L
0755-4982
Publication state
Published
Issued date
2002
Volume
31
Number
18
Pages
828-33
Language
french
Notes
Presne, C
Fakhouri, F
Kenouch, S
Stengel, B
Kreis, H
Grunfeld, J P
fre
English Abstract
France
Presse Med. 2002 May 25;31(18):828-33.
Fakhouri, F
Kenouch, S
Stengel, B
Kreis, H
Grunfeld, J P
fre
English Abstract
France
Presse Med. 2002 May 25;31(18):828-33.
Abstract
OBJECTIVES: Study the renal consequences of lithium therapy and find out whether lithium-induced chronic renal toxicity can provoke a progressive nephropathy, leading to advanced renal failure, requiring periodical dialysis. METHODS: Fifty-three patients treated with long-term lithium salts were included in the study. They had developed chronic renal failure (creatinine clearance inferior to 80 ml/min) not due to any other cause. RESULTS: These patients had received lithium salts for a mean period of 17.7 years. The mean reduction in creatinine clearance was of 2.23 ml/min/year. Final clearance correlated negatively with the duration of lithium administration. In 7 patients treated a mean of 22 years, progression towards terminal kidney failure required periodical dialysis. Around 30% of patients exhibited mild hypercalcemia. CONCLUSION: Lithium nephropathy inducing progressive renal failure is a reality. Its prevalence in patients treated long-term with lithium should be assessed.
Keywords
Adult, Bipolar Disorder/blood/*drug therapy, Creatinine/blood, Dose-Response Relationship, Drug, Female, Glomerular Filtration Rate/drug effects, Humans, Kidney Failure, Chronic/blood/*chemically induced/diagnosis, Kidney Function Tests, Lithium Compounds/administration & dosage/*adverse effects/pharmacokinetics, Long-Term Care, Male, Middle Aged, Renal Dialysis
Pubmed
Create date
01/03/2022 10:18
Last modification date
02/03/2022 6:36