Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis.

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State: Public
Version: author
Serval ID
serval:BIB_C482F2C2CABE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis.
Journal
Journal of Hepatology
Author(s)
Cai Tao, Dufour Jean-François, Muellhaupt Beat, Gerlach Tilman, Heim Markus, Moradpour Darius, Cerny Andreas, Malinverni Raffaele, Kaddai Vincent, Bochud Murielle, Negro Francesco, Bochud Pierre-Yves
Working group(s)
on behalf of the Swiss Hepatitis C Cohort Study Group
ISSN
0168-8278 (Electronic)
ISSN-L
0168-8278
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
55
Number
3
Pages
529-535
Language
english
Abstract
BACKGROUND & AIMS: Steatosis is a prominent feature of hepatitis C, especially in patients infected with genotype 3. The analysis of genetic polymorphisms influencing steatosis in chronic hepatitis C has been limited by the studies' small sample size, and important single nucleotide polymorphisms (SNPs), such as those in the patatin-like phospholipase family 3 protein (PNPLA3), were never evaluated. METHODS: We analyzed the role of SNPs, from 19 systematically selected candidate genes, on steatosis in 626 Caucasian hepatitis C virus (HCV) infected patients. SNPs were extracted from a genome-wide association-generated dataset. Associations of alleles with the presence and/or different severity of steatosis were evaluated by univariate and multivariate logistic regression, accounting for all relevant covariates. RESULTS: The risk of steatosis was increased by carriage of I148M in PNPLA3, but only in patients with HCV genotypes non-3 (odds ratio [OR]=1.9, 95% confidence interval [CI]=1.6-2.3, p<0.001) and similar, albeit weaker associations were found for SNPs in peroxisome proliferator-activated receptor-γ (PPARG) and interleukin-28B (IL28B). Carriage of a SNP in the microsomal triglyceride transfer protein (MTTP) increased the risk of steatosis, but only in patients with HCV genotype 3 (rs1800803, OR=3.4, 95% CI=2.4-4.9, p=0.001). CONCLUSIONS: The rs738409 SNP in PNPLA3 is associated with an increased risk of steatosis in patients infected with HCV genotypes non-3. Host genes affect steatosis depending on the infecting HCV genotype, suggesting their interaction with viral factors.
Pubmed
Web of science
Create date
01/09/2011 7:43
Last modification date
20/08/2019 15:39
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